作者
Matti Kesti, Christian Eberhardt, Guglielmo Pagliccia, David Kenkel, Daniel Grande, Andreas Boss, Marcy Zenobi‐Wong
发表日期
2015/12
期刊
Advanced Functional Materials
卷号
25
期号
48
页码范围
7406-7417
简介
Bioprinting is an emerging technology for the fabrication of patient‐specific, anatomically complex tissues and organs. A novel bioink for printing cartilage grafts is developed based on two unmodified FDA‐compliant polysaccharides, gellan and alginate, combined with the clinical product BioCartilage (cartilage extracellular matrix particles). Cell‐friendly physical gelation of the bioink occurs in the presence of cations, which are delivered by co‐extrusion of a cation‐loaded transient support polymer to stabilize overhanging structures. Rheological properties of the bioink reveal optimal shear thinning and shear recovery properties for high‐fidelity bioprinting. Tensile testing of the bioprinted grafts reveals a strong, ductile material. As proof of concept, 3D auricular, nasal, meniscal, and vertebral disk grafts are printed based on computer tomography data or generic 3D models. Grafts after 8 weeks in vitro are scanned …
引用总数
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