作者
Vincent Yi‐Fong Su, Yu‐Wen Hu, Kun‐Ta Chou, Shuo‐Ming Ou, Yu‐Chin Lee, Elizabeth Ya‐Hsuan Lin, Tzeng‐Ji Chen, Cheng‐Hwai Tzeng, Chia‐Jen Liu
发表日期
2013/5/1
期刊
Cancer
卷号
119
期号
9
页码范围
1699-1705
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
BACKGROUND
In postmarketing surveillance, the US Food and Drug Administration has reported the development of lung masses, thyroid cancer, and skin cancer after amiodarone therapy.
METHODS
Using the Taiwan National Health Insurance Research database, the authors conducted a population‐based cohort study. Patients who were treated with amiodarone between 1997 and 2008 were enrolled. Those with antecedent cancer were excluded. Standardized incidence ratios (SIRs) of cancers were calculated to compare the cancer incidence of the study cohort with that of the general population. A multivariate Cox regression model was used to evaluate the association between cumulative defined daily doses (cDDDs) of amiodarone and cancer occurrence.
RESULTS
The study included 6418 subjects, with a median follow‐up of 2.57 years. A total of 280 patients developed cancer. The risk of cancer …
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VYF Su, YW Hu, KT Chou, SM Ou, YC Lee, EYH Lin… - Cancer, 2013