作者
Francesca J Torriani, Lauren Komarow, Robert A Parker, Bruno R Cotter, Judith S Currier, Michael P Dubé, Carl J Fichtenbaum, Mariana Gerschenson, Carol KC Mitchell, Robert L Murphy, Kathleen Squires, James H Stein, ACTG 5152s Study Team
发表日期
2008/8/12
期刊
Journal of the American College of Cardiology
卷号
52
期号
7
页码范围
569-576
出版商
American College of Cardiology Foundation
简介
Objectives
This study evaluated the effects of 3 class-sparing antiretroviral therapy (ART) regimens on endothelial function in human immunodeficiency virus (HIV)-infected subjects participating in a randomized trial.
Background
Endothelial dysfunction has been observed in patients receiving ART for HIV infection.
Methods
This was a prospective, multicenter study of treatment-naive subjects who were randomly assigned to receive a protease inhibitor-sparing regimen of nucleoside reverse transcriptase inhibitors (NRTIs) + efavirenz, a non-nucleoside reverse transcriptase inhibitor-sparing regimen of NRTIs + lopinavir/ritonavir, or a NRTI-sparing regimen of efavirenz + lopinavir/ritonavir. The NRTIs were lamivudine + stavudine, zidovudine, or tenofovir. Brachial artery flow-mediated dilation (FMD) was determined by B-mode ultrasound before starting on ART, then after 4 and 24 weeks.
Results
There were 82 subjects …
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