查看文章

ADAMTS-1 is a multi-domain, multi-functional matrix metalloproteinase expressed in the mouse ovary during folliculogenesis and ovulation. Adult ADAMTS-1 null female mice are infertile; however, the exact mechanism responsible for their reproductive failure is yet to be explained. ADAMTS-1 null ovaries prior to and following ovulation were examined and a defect in ovarian follicle development was identified. A classification system was devised and used to identify morphological differences between normal and ADAMTS-1 null ovaries. The phenotype indicated a progressive loss of follicle structural integrity ranging from a slight loss of shape, to full structural dysgenesis. As a result, large numbers of oocytes with healthy appearance were found with no surrounding follicle structure. The numbers of preantral follicles was not altered, but type 6 (early antral) follicles in the ADAMTS-1 null ovaries were significantly …