作者
Deborah T Blumenthal, Thierry Gorlia, Mark R Gilbert, Michelle M Kim, L Burt Nabors, Warren P Mason, Monika E Hegi, Peixin Zhang, Vassilis Golfinopoulos, James R Perry, Do Hyun Nam, Sara C Erridge, Benjamin W Corn, René O Mirimanoff, Paul D Brown, Brigitta G Baumert, Minesh P Mehta, Martin J van den Bent, David A Reardon, Michael Weller, Roger Stupp
发表日期
2017/8/1
期刊
Neuro-oncology
卷号
19
期号
8
页码范围
1119-1126
出版商
Oxford University Press
简介
Background
Radiation with concurrent and adjuvant (6 cycles) temozolomide (TMZ) is the established standard of postsurgical care for newly diagnosed glioblastoma (GBM). This regimen has been adopted with variations, including extending TMZ beyond 6 cycles. The optimal duration of maintenance therapy remains controversial.
Methods
We performed pooled analysis of individual patient data from 4 randomized trials for newly diagnosed GBM. All patients who were progression free 28 days after cycle 6 were included. The decision to continue TMZ was per local practice and standards, and at the discretion of the treating physician. Patients were grouped into those treated with 6 cycles and those who continued beyond 6 cycles. Progression-free and overall survival were compared, adjusted by age, performance status, resection extent, and MGMT methylation …
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DT Blumenthal, T Gorlia, MR Gilbert, MM Kim… - Neuro-oncology, 2017