作者
Leor Zach, David Guez, David Last, Dianne Daniels, Yuval Grober, Ouzi Nissim, Chen Hoffmann, Dvora Nass, Alisa Talianski, Roberto Spiegelmann, Galia Tsarfaty, Sharona Salomon, Moshe Hadani, Andrew Kanner, Deborah T Blumenthal, Felix Bukstein, Michal Yalon, Jacob Zauberman, Jonathan Roth, Yigal Shoshan, Evgeniya Fridman, Marc Wygoda, Dror Limon, Tzahala Tzuk, Zvi R Cohen, Yael Mardor
发表日期
2015/3/1
期刊
Neuro-oncology
卷号
17
期号
3
页码范围
457-465
出版商
Oxford University Press
简介
Background
Conventional magnetic resonance imaging (MRI) is unable to differentiate tumor/nontumor enhancing tissues. We have applied delayed-contrast MRI for calculating high resolution treatment response assessment maps (TRAMs) clearly differentiating tumor/nontumor tissues in brain tumor patients.
Methods
One hundred and fifty patients with primary/metastatic tumors were recruited and scanned by delayed-contrast MRI and perfusion MRI. Of those, 47 patients underwent resection during their participation in the study. Region of interest/threshold analysis was performed on the TRAMs and on relative cerebral blood volume maps, and correlation with histology was studied. Relative cerebral blood volume was also assessed by the study neuroradiologist.
Results
Histological validation confirmed that regions of contrast agent clearance in the …
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L Zach, D Guez, D Last, D Daniels, Y Grober, O Nissim… - Neuro-oncology, 2015