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Marine organisms are rich source of bioactive secondary metabolites. The remarkable abundance and diversity of bioactive small molecule that has been isolated from soft corals, sponges, ascidian and other marine invertebrates have made these organisms an important source of new drug candidates for human diseases, particularly antimicrobial activity. The methanolic extract of an Indonesian soft coral Sinularia sp. showed potent activity against Bacillus substilis, Escherichia coli, Vibrio eltor and Staphylococcus aureus. Phytochemical screening revealed the presence of alkaloid, saponin, terpenoid, steroid and glycoside in the methanolic extract of Sinularia sp. Fraction 7 from ethyl acetate portion of Sinularia sp. extract showed good activity against Vibrio eltor (MIC= 125 μg· mL–1).