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As a tropical archipelago country, Indonesia has a mega diversity of marine organisms, such as sponges. About 850 species of sponges were identified from the east part of Indonesia. The uniqueness of Indonesian marine sponges attracted many researchers to explore the sponge's potential in producing active substances. During 1995-2016, about 40 genera of Indonesian sponges were investigated for their potential in producing pharmacological activity such as antimicrobial, anticancer, antivirus, multidrug-resistant (MDR), etc. The data showed that 56.7% of 430 reported compounds were confirmed as new compounds. The research trend on Indonesian sponges was high during 2004-2013, but decreasing after 2014. However, researches in the term of active substances from marine sponges should find provide the basic skeleton of anti-cancer drug lead compounds. Chemical structure diversity plays an …