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Exposure of pregnant rats to electromagnetic field (EMF) of 50 Hz and 2 millitesla (2 mT), showed many deleterious changes in the spleen of these rats and their foetuses. Many histological, histochemical and ultrastructural changes were observed in foetal and maternal spleen. Altered polysaccharides, protein content and collagenous bundles were detected in spleen of pregnant rats and their foetuses. Foetal spleen appeared more sensitive to the electromagnetic field than the maternal spleen. Also mitochondria of WBCs were highly sensitive to these fields than Golgi apparatus.