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Background: Sensory neurons play an essential role in almost all pain conditions, and have recently been classified into distinct subsets on the basis of their transcriptomes. Here we have analysed alterations in dorsal root ganglia (DRG) gene expression using microarrays in mouse models related to human chronic pain.

Methods: Six different pain models were studied in male C57BL/6J mice:(1) bone cancer pain using cancer cell injection in the intramedullary space of the femur;(2) neuropathic pain using partial sciatic nerve ligation;(3) osteoarthritis pain using mechanical joint loading;(4) chemotherapy-induced pain with oxaliplatin;(5) chronic muscle pain using hyperalgesic priming; and (6) inflammatory pain using intraplantar complete Freund’s adjuvant. Microarray analyses were performed using RNA isolated from dorsal root ganglia and compared to sham/vehicle treated controls.

Results: Differentially …