作者
Tyler J Moss, Yuan Qi, Liu Xi, Bo Peng, Tae-Beom Kim, Nader E Ezzedine, Maribel E Mosqueda, Charles C Guo, Bogdan A Czerniak, Michael Ittmann, David A Wheeler, Seth P Lerner, Surena F Matin
发表日期
2017/10/1
期刊
European urology
卷号
72
期号
4
页码范围
641-649
出版商
Elsevier
简介
Background
Upper urinary tract urothelial cancer (UTUC) may have unique etiologic and genomic factors compared to bladder cancer.
Objective
To characterize the genomic landscape of UTUC and provide insights into its biology using comprehensive integrated genomic analyses.
Design, setting, and participants
We collected 31 untreated snap-frozen UTUC samples from two institutions and carried out whole-exome sequencing (WES) of DNA, RNA sequencing (RNAseq), and protein analysis.
Outcome measurements and statistical analysis
Adjusting for batch effects, consensus mutation calls from independent pipelines identified DNA mutations, gene expression clusters using unsupervised consensus hierarchical clustering (UCHC), and protein expression levels that were correlated with relevant clinical variables, The Cancer Genome Atlas, and other published data.
Results and limitations
WES identified …
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TJ Moss, Y Qi, L Xi, B Peng, TB Kim, NE Ezzedine… - European urology, 2017