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Lysine acetylsalicylate (LAS) is an analgesic used for the prevention of cardiovascular disease with few adverse though its effect on the hepatorenal and hematological parameters remains unclear. 45 mature male Wistar rats were equally divided into three groups. Group I, II, and III received daily intramuscular doses of 0.25 mL saline, 40, and 80 mg/kg b. wt. of LAS respectively for 2-weeks. After 2, 4, and 8 weeks from beginning of drug administration, 5 rats/group were assessed for hepatorenal function, complete blood-count, and histopathological findings of liver and kidney. LAS induced a significant increase (p ≤ 0.05) in serum levels of aspartate aminotransferase, alanine aminotransferase, urea, and creatinine in a dose-dependent manner, but a significant decrease (p ≤ 0.05) observed in the hematological parameters. Histopathological alterations were a dose-dependent manner, and persisted for 8 …