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Let M be a left R-module. In this paper a generalization of the notion of an s-system of rings to modules is given. Let N be a submodule of M. Define $\mathcal{S}(N):=\{ {m\in M}:\, \mbox{every } s\mbox{-system containing } m \mbox{ meets}~N \}$. It is shown that $\mathcal{S}(N)$ is equal to the intersection of all s-prime submodules of M containing N. We define $\mathcal{N}({}_{R}M) = \mathcal{S}(0)$. This is called (Köthe’s) upper nil radical of M. We show that if R is a commutative ring, then $\mathcal{N}({}_{R}M) = {\mathop{\mathrm{rad}}\nolimits}_{R}(M)$ where ${\mathop{\mathrm{rad}}\nolimits}_{R}(M)$ denotes the prime radical of M. We also show that if R is a left Artinian ring, then ${\mathop{\mathrm{rad}}\nolimits}_{R}(M)=\mathcal{N}({}_{R}M)= {\mathop{\mathrm{Rad}}\nolimits}\, (M)= {\mathop{\mathrm{Jac}}\nolimits}\, (R)M$ where ${\mathop{\mathrm{Rad}}\nolimits}\, (M)$ denotes the Jacobson radical …