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An extraordinary surge in the methodologi-cal diversity of clinical research studies has occurred during the past 2 decades, with a recent dramatic rise in the scope and sophistication of mixed methods designs. 1, 2 Mixed methods (also known as multimethod) research involves integrating quantitative and qualitative approaches to generating new knowledge3 and can involve either concurrent or sequential use of these 2 classes of methods to follow a line of inquiry. 4, 5 Combining methods activates their complementary strengths and helps to overcome their discrete weaknesses. 6 Increasingly, integrated mixed methods designs allow researchers to follow emerging questions, rather than limiting their research to questions that are amenable to a particular method. 7 Multimethod research brings together numbers and narratives, description, hypothesis testing, hypothesis generation, and understanding of meaning …