作者
Xinyu Zhou, Gabor I Keitner, Bin Qin, Arun V Ravindran, Michael Bauer, Cinzia Del Giovane, Jingping Zhao, Yiyun Liu, Yiru Fang, Yuqing Zhang, Peng Xie
发表日期
2015/10/1
来源
International Journal of Neuropsychopharmacology
卷号
18
期号
11
页码范围
pyv060
出版商
Oxford University Press
简介
Background
Previous meta-analyses of atypical antipsychotics for depression were limited by few trials with direct comparisons between two treatments. We performed a network meta-analysis, which integrates direct and indirect evidence from randomized controlled trials (RCTs), to investigate the comparative efficacy and tolerability of adjunctive atypical antipsychotics for treatment-resistant depression (TRD).
Methods
Systematic searches resulted in 18 RCTs (total n = 4422) of seven different types and different dosages of atypical antipsychotics and a placebo that were included in the review.
Results
All standard-dose atypical antipsychotics were significantly more efficacious than placebo in the efficacy (standardized mean differences [SMDs] ranged from -0.27 to -0.43). There were no significant differences between these drugs. Low-dose atypical …
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X Zhou, GI Keitner, B Qin, AV Ravindran, M Bauer… - International Journal of Neuropsychopharmacology, 2015