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Astrocytes are the most common glial cells in the brain with fine processes and endfeet that intimately contact both neuronal synapses and the cerebral vasculature. They play an important role in mediating neurovascular coupling (NVC) via several astrocytic Ca²⁺‐dependent signalling pathways such as K⁺ release through B_K channels, and the production and release of arachidonic acid metabolites. They are also involved in maintaining the resting tone of the cerebral vessels by releasing ATP and COX‐1 derivatives. Evidence also supports a role for astrocytes in maintaining blood pressure‐dependent change in cerebrovascular tone, and perhaps also in blood vessel‐to‐neuron signalling as posited by the ‘hemo‐neural hypothesis’. Thus, astrocytes are emerging as new stars in preserving the intricate balance between the high energy demand of active neurons and the supply of oxygen and nutrients from the …