查看文章

Background

Thrombus formation is the result of the disruption of the complex homeostatic system involving platelets, coagulation factors, inflammatory elements, cytokines, and the endothelium (Citation 1). Platelets play a central role in the initiation and propagation of thrombus formation (Citation 1). After platelet adhesion-which is mediated by the interaction between the glycoprotein (GP) Ib-IX-V and von Willebrand factor, and the GPVI receptor which binds directly to collagen-multiple intracellular pathways are responsible for platelet activation (Citation 1). The released adenosine diphosphate (ADP) acts on P2Y 1 and, most importantly, on P2Y 12 receptors on the platelet surface (Citation 1). While P2Y 1 receptor while P2Y1 receptor activation leads to an initial mobilization of intracellular calcium ions from internal stores resulting in platelet shape change, the P2Y 12 receptor is a G protein-coupled receptor that …