作者
Massumeh Saadatmand, Ghaidaa Raheem Lateef Al-Awsi, Abdullah D Alanazi, Asghar Sepahvand, Mojtaba Shakibaie, Saeedeh Shojaee, Rasool Mohammadi, Hossein Mahmoudvand
发表日期
2021/11/1
期刊
Saudi journal of biological sciences
卷号
28
期号
11
页码范围
6454-6460
出版商
Elsevier
简介
Background
Today, a suitable vaccine has not yet been discovered to prevent Toxoplasma gondii infection. Therefore, prophylaxis can be suggested as the preferred approach to prevent toxoplasmosis. This study aims to evaluate the prophylactic effects of synthesized zinc nanoparticles (ZnNPs) using Lavandula angustifolia Vera., by microwave method on chronic toxoplasmosis in mice.
Methods
BALB/c Mice orally administrated with ZnNPs the doses of 32.5, 75, 150 mg/kg/day for two weeks. On the 15th day, the mice were intraperitoneally infected with the Tehran strain of T. gondii (25 tissue cysts). The mean diameter and the numbers of brain tissue cysts, as well as the mRNA levels of inducible nitric oxide synthesize (iNOs), and interferon-gamma (IFN-γ) in mice of each experimental group were evaluated.
Results
The synthesized ZnNPs represent a spherical form with a size ranging from 30 to 80 nm. The results …
学术搜索中的文章
M Saadatmand, GRL Al-Awsi, AD Alanazi… - Saudi journal of biological sciences, 2021