作者
Haleh Pak, Alireza Hadizadeh, Asieh Heirani‐Tabasi, Masoud Soleimani, Reza Akbari Asbagh, Mohammad Sadegh Fazeli, Alireza Kazemeini, Amir Keshvari, Mohammad Reza Keramati, Faezeh Salahshour, Hengameh Nazari, Seyed Mohsen Ahmadi Tafti, Behnam Behboudi
发表日期
2023/4
期刊
Journal of Gastroenterology and Hepatology
卷号
38
期号
4
页码范围
539-547
简介
Background and Aim
A perianal fistula is an abnormal tract that connects anal canal to skin. Current medical and surgical interventions have a high failure rate particularly in complex and refractory cases. MSC‐derived exosomes have demonstrated immunomodulatory effects without the conventional complications; hence, in this study, we evaluated the safety of their application for complex perianal fistula.
Methods
Placenta‐derived MSCs were cultured, and exosomes were isolated using ultracentrifugation. Exosome injections were administered in the operating room to 11 patients with complex perianal fistula (presence of fistulas for at least 1 year alongside medical and surgical treatment). The patients were followed for 6 months, and the patients were evaluated using physical examination, face‐to‐face interviews, and magnetic resonance imaging (MRI).
Results
Among 11 patients only one did not show any …
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H Pak, A Hadizadeh, A Heirani‐Tabasi, M Soleimani… - Journal of Gastroenterology and Hepatology, 2023