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Isoprenoid glycerol dialkyl glycerol tetraethers (isoGDGTs) of archaeal origin and branched (br)GDGTs of bacterial origin occur in a diverse range of lacustrine sedimentary environments. They have attracted attention as potential temperature proxies, providing high resolution (palaeo)environmental reconstruction from continental interiors. For this study, the distribution of GDGTs in, and application of GDGT-based proxies to, surface samples from Chaka Salt Lake (China), as well as soils and in-flow river sediments, were investigated to assess whether GDGT-based proxies were applicable to this hypersaline lake system. We show that iso- and brGDGTs were present in all sediments and soils from the Chaka Salt Lake system. GDGT-0 and crenarchaeol were generally the two most abundant isoGDGTs, suggesting Thaumarchaeota as a major biological source of isoGDGTs. The low ratio of crenarchaeol …