作者
Natalie J Bitto, Paul J Baker, Jennifer K Dowling, Georgie Wray‐McCann, Amanda De Paoli, Le Son Tran, Pak Ling Leung, Katryn J Stacey, Ashley Mansell, Seth L Masters, Richard L Ferrero
发表日期
2018/11
期刊
Immunology and Cell Biology
卷号
96
期号
10
页码范围
1120-1130
简介
Outer membrane vesicles (OMVs) are constitutively produced by Gram‐negative bacteria both in vivo and in vitro. These lipid‐bound structures carry a range of immunogenic components derived from the parent cell, which are transported into host target cells and activate the innate immune system. Recent advances in the field have shed light on some of the multifaceted roles of OMVs in host–pathogen interactions. In this study, we investigated the ability of OMVs from two clinically important pathogens, Pseudomonas aeruginosa and Helicobacter pylori, to activate canonical and noncanonical inflammasomes. P. aeruginosa OMVs induced inflammasome activation in mouse macrophages, as evidenced by “speck” formation, as well as the cleavage and secretion of interleukin‐1β and caspase‐1. These responses were independent of AIM2 and NLRC4 canonical inflammasomes, but dependent on the …
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NJ Bitto, PJ Baker, JK Dowling, G Wray‐McCann… - Immunology and Cell Biology, 2018