作者
Julia Hippisley-Cox, Duncan Young, Carol Coupland, Keith M Channon, Pui San Tan, David A Harrison, Kathryn Rowan, Paul Aveyard, Ian D Pavord, Peter J Watkinson
发表日期
2020/10/1
期刊
Heart
卷号
106
期号
19
页码范围
1503-1511
出版商
BMJ Publishing Group Ltd and British Cardiovascular Society
简介
Background
There is uncertainty about the associations of angiotensive enzyme (ACE) inhibitor and angiotensin receptor blocker (ARB) drugs with COVID-19 disease. We studied whether patients prescribed these drugs had altered risks of contracting severe COVID-19 disease and receiving associated intensive care unit (ICU) admission.
Methods
This was a prospective cohort study using routinely collected data from 1205 general practices in England with 8.28 million participants aged 20–99 years. We used Cox proportional hazards models to derive adjusted HRs for exposure to ACE inhibitor and ARB drugs adjusted for sociodemographic factors, concurrent medications and geographical region. The primary outcomes were: (a) COVID-19 RT-PCR diagnosed disease and (b) COVID-19 disease resulting in ICU care.
Findings
Of 19 486 patients who had COVID-19 disease, 1286 received ICU care. ACE …
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J Hippisley-Cox, D Young, C Coupland, KM Channon… - Heart, 2020