作者
Catherine Mark, Soheil Meshinchi, Brooklyn Joyce, Brenda Gibson, Christine Harrison, Anke K Bergmann, Bianca F Goemans, Cornelis Jan H Pronk, Helene Lapillonne, Guy Leverger, Evangelia Antoniou, Markus Schneider, Andishe Attarbaschi, Michael Dworzak, Jan Stary, Daisuke Tomizawa, Sabine Ebert, Monika Lejman, E Anders Kolb, Kjeld Schmiegelow, Henrik Hasle, Oussama Abla
发表日期
2024/2
期刊
British Journal of Haematology
卷号
204
期号
2
页码范围
576-584
简介
The prognostic impact of PICALM::MLLT10 status in childhood leukaemia is not well described. Ten International Berlin Frankfurt Münster‐affiliated study groups and the Children's Oncology Group collaborated in this multicentre retrospective study. The presence of the PICALM::MLLT10 fusion gene was confirmed by fluorescence in situ hybridization and/or RNA sequencing at participating sites. Ninety‐eight children met the study criteria. T‐cell acute lymphoblastic leukaemia (T‐ALL) and acute myeloid leukaemia (AML) predominated 55 (56%) and 39 (40%) patients, respectively. Most patients received a chemotherapy regimen per their disease phenotype: 58% received an ALL regimen, 40% an AML regimen and 1% a hybrid regimen. Outcomes for children with PICALM::MLLT10 ALL were reasonable: 5‐year event‐free survival (EFS) 67% and 5‐year overall survival (OS) 76%, but children with PICALM …
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C Mark, S Meshinchi, B Joyce, B Gibson, C Harrison… - British Journal of Haematology, 2024