作者
Simon Bomken, Amir Enshaei, Edward C Schwalbe, Aneta Mikulasova, Yunfeng Dai, Masood Zaka, Kent TM Fung, Matthew Bashton, Huezin Lim, Lisa Jones, Nefeli Karataraki, Emily Winterman, Cody Ashby, Andishe Attarbaschi, Yves Bertrand, Jutta Bradtke, Barbara Buldini, GA Amos Burke, Giovanni Cazzaniga, Gudrun Göhring, Hesta A de Groot-Kruseman, Claudia Haferlach, Luca Lo Nigro, Mayur Parihar, Adriana Plesa, Emma Seaford, Edwin Sonneveld, Sabine Strehl, Vincent HJ Van der Velden, Vikki Rand, Stephen P Hunger, Christine J Harrison, Chris M Bacon, Frederik W Van Delft, Mignon L Loh, John Moppett, Josef Vormoor, Brian A Walker, Anthony V Moorman, Lisa J Russell
发表日期
2023/3/3
期刊
Haematologica
卷号
108
期号
3
页码范围
717
出版商
Ferrata Storti Foundation
简介
Rarely, immunophenotypically immature B-cell precursor acute lymphoblastic leukemia (BCP-ALL) carries an immunoglobulin-MYC rearrangement (IG-MYC-r). This can result in diagnostic confusion with Burkitt lymphoma/leukemia and use of individualized treatment schedules of unproven efficacy. Here we compare the molecular characteristics of these conditions and investigate historic clinical outcome data. We identified 90 cases registered in a national BCP-ALL clinical trial/registry. When present, diagnostic material underwent cytogenetic, exome, methylome and transcriptome analyses. The outcomes analyzed were 3-year event-free survival and overall survival. IG-MYC-r was identified in diverse cytogenetic backgrounds, co-existing with either established BCP-ALL-specific abnormalities (high hyperdiploidy, n= 3; KMT2A-rearrangement, n= 6; iAMP21, n= 1; BCR-ABL1, n= 1); BCL2/BCL6-rearrangements …
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S Bomken, A Enshaei, EC Schwalbe, A Mikulasova… - Haematologica, 2023