作者
Arian Van der Veer, Esmé Waanders, Rob Pieters, Marieke E Willemse, Simon V Van Reijmersdal, Lisa J Russell, Christine J Harrison, William E Evans, Vincent HJ van der Velden, Peter M Hoogerbrugge, Frank Van Leeuwen, Gabriele Escherich, Martin A Horstmann, Leila Mohammadi Khankahdani, Dimitris Rizopoulos, Hester A De Groot-Kruseman, Edwin Sonneveld, Roland P Kuiper, Monique L Den Boer
发表日期
2013/10/10
期刊
Blood, The Journal of the American Society of Hematology
卷号
122
期号
15
页码范围
2622-2629
出版商
American Society of Hematology
简介
Most relapses in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are not predicted using current prognostic features. Here, we determined the co-occurrence and independent prognostic relevance of 3 recently identified prognostic features: BCR-ABL1-like gene signature, deletions in IKZF1, and high CRLF2 messenger RNA expression (CRLF2-high). These features were determined in 4 trials representing 1128 children with ALL: DCOG ALL-8, ALL9, ALL10, and Cooperative ALL (COALL)-97/03. BCR-ABL1-like, IKZF1-deleted, and CRLF2-high cases constitute 33.7% of BCR-ABL1–negative, MLL wild-type BCP-ALL cases, of which BCR-ABL1-like and IKZF1 deletion (co)occurred most frequently. Higher cumulative incidence of relapse was found for BCR-ABL1-like and IKZF1-deleted, but not CRLF2-high, cases relative to remaining BCP-ALL cases, reflecting the observations in each of …
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A Van der Veer, E Waanders, R Pieters, ME Willemse… - Blood, The Journal of the American Society of …, 2013