作者
Andishe Attarbaschi, Anja Möricke, Christine J Harrison, Georg Mann, André Baruchel, Barbara De Moerloose, Valentino Conter, Meenakshi Devidas, Sarah Elitzur, Gabriele Escherich, Stephen P Hunger, Keizo Horibe, Atsushi Manabe, Mignon L Loh, Rob Pieters, Kjeld Schmiegelow, Lewis B Silverman, Jan Stary, Ajay Vora, Ching-Hon Pui, Martin Schrappe, Martin Zimmermann, Ponte-di-Legno Childhood Acute Lymphoblastic Leukemia Working Group
发表日期
2023/3/1
期刊
Journal of Clinical Oncology
卷号
41
期号
7
页码范围
1404-1422
出版商
Wolters Kluwer Health
简介
PURPOSE
We aimed to study prognostic factors and efficacy of allogeneic hematopoietic stem-cell transplantation (allo-HSCT) in first remission of patients with noninfant childhood acute lymphoblastic leukemia (ALL) with 11q23/KMT2A rearrangements treated with chemotherapy regimens between 1995 and 2010.
PATIENTS AND METHODS
Data were retrospectively retrieved from 629 patients with 11q23/KMT2A-rearranged ALL from 17 members of the Ponte-di-Legno Childhood ALL Working Group. Clinical and biologic characteristics, early response assessed by minimal residual disease at the end of induction (EOI) therapy, and allo-HSCT were analyzed for their impact on outcomes.
RESULTS
A specific 11q23/KMT2A translocation partner gene was identified in 84.3% of patients, with the most frequent translocations being t(4;11)(q21;q23) (n = 273; 51.5%), t(11;19)(q23;p13.3) (n = 106; 20.0%), t(9;11)(p21_22 …
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A Attarbaschi, A Möricke, CJ Harrison, G Mann… - Journal of Clinical Oncology, 2023