作者
Amy L Sherborne, Fay J Hosking, Rashmi B Prasad, Rajiv Kumar, Rolf Koehler, Jayaram Vijayakrishnan, Elli Papaemmanuil, Claus R Bartram, Martin Stanulla, Martin Schrappe, Andreas Gast, Sara E Dobbins, Yussanne Ma, Eamonn Sheridan, Malcolm Taylor, Sally E Kinsey, Tracey Lightfoot, Eve Roman, Julie AE Irving, James M Allan, Anthony V Moorman, Christine J Harrison, Ian P Tomlinson, Sue Richards, Martin Zimmermann, Csaba Szalai, Agnes F Semsei, Daniel J Erdelyi, Maja Krajinovic, Daniel Sinnett, Jasmine Healy, Anna Gonzalez Neira, Norihiko Kawamata, Seishi Ogawa, H Phillip Koeffler, Kari Hemminki, Mel Greaves, Richard S Houlston
发表日期
2010/6
期刊
Nature genetics
卷号
42
期号
6
页码范围
492-494
出版商
Nature Publishing Group US
简介
Using data from a genome-wide association study of 907 individuals with childhood acute lymphoblastic leukemia (cases) and 2,398 controls and with validation in samples totaling 2,386 cases and 2,419 controls, we have shown that common variation at 9p21.3 (rs3731217, intron 1 of CDKN2A) influences acute lymphoblastic leukemia risk (odds ratio = 0.71, P = 3.01 × 10−11), irrespective of cell lineage.
引用总数
学术搜索中的文章
AL Sherborne, FJ Hosking, RB Prasad, R Kumar… - Nature genetics, 2010