作者
Malav S Trivedi, Jayni S Shah, Sara Al-Mughairy, Nathaniel W Hodgson, Benjamin Simms, Geert A Trooskens, Wim Van Criekinge, Richard C Deth
发表日期
2014/10/1
期刊
The Journal of nutritional biochemistry
卷号
25
期号
10
页码范围
1011-1018
出版商
Elsevier
简介
Dietary interventions like gluten-free and casein-free diets have been reported to improve intestinal, autoimmune and neurological symptoms in patients with a variety of conditions; however, the underlying mechanism of benefit for such diets remains unclear. Epigenetic programming, including CpG methylation and histone modifications, occurring during early postnatal development can influence the risk of disease in later life, and such programming may be modulated by nutritional factors such as milk and wheat, especially during the transition from a solely milk-based diet to one that includes other forms of nutrition. The hydrolytic digestion of casein (a major milk protein) and gliadin (a wheat-derived protein) releases peptides with opioid activity, and in the present study, we demonstrate that these food-derived proline-rich opioid peptides modulate cysteine uptake in cultured human neuronal and gastrointestinal …
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MS Trivedi, JS Shah, S Al-Mughairy, NW Hodgson… - The Journal of nutritional biochemistry, 2014