作者
Linda Wiltzer, Florence Larrous, Sibil Oksayan, Naoto Ito, Glenn A Marsh, LF Wang, D Blondel, Hervé Bourhy, DA Jans, GW Moseley
发表日期
2012/9/15
期刊
Journal of virology
卷号
86
期号
18
页码范围
10194-10199
出版商
American Society for Microbiology
简介
The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.
学术搜索中的文章
L Wiltzer, F Larrous, S Oksayan, N Ito, GA Marsh… - Journal of virology, 2012