作者
Suetonia C Palmer, Jonathan C Craig, Sankar D Navaneethan, Marcello Tonelli, Fabio Pellegrini, Giovanni FM Strippoli
发表日期
2012/8/21
来源
Annals of internal medicine
卷号
157
期号
4
页码范围
263-275
出版商
American College of Physicians
简介
Background
Statins have uncertain benefits in persons with chronic kidney disease (CKD) because individual trials may have insufficient power to determine whether treatment effects differ with severity of CKD.
Purpose
To summarize the benefits and harms of statin therapy for adults with CKD and examine whether effects of statins vary by stage of kidney disease.
Data Sources
Cochrane and EMBASE databases (inception to February 2012).
Study Selection
Randomized trials comparing the effects of statins with placebo, no treatment, or another statin on mortality and cardiovascular outcomes.
Data Extraction
Two independent reviewers extracted data and assessed risk of bias.
Data Synthesis
Eighty trials comprising 51 099 participants …
学术搜索中的文章
SC Palmer, JC Craig, SD Navaneethan, M Tonelli… - Annals of internal medicine, 2012