作者
Anne-Sophie Lamort, Ioanna Giopanou, Ioannis Psallidas, Georgios T Stathopoulos
发表日期
2019/8/2
来源
Cells
卷号
8
期号
8
页码范围
815
出版商
MDPI
简介
The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples.
引用总数
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