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Aims:

This study has been designed to investigation the anticancer effects of simvastatin on breast CSCs.

Settings and Design:

In this study, MCF-7 CSCs were isolated from parent cells and cytotoxic effects of simvastatin were evaluated and compared in both cells.

Subjects and Methods:

Stem cell isolation was done by flow cytometry technique and the effects of simvastatin on the stem cell viability, apoptosis and cell cycle were evaluated and compared with parent cells.

Statistical Analysis Used:

The results were analyzed using one-way ANOVA, followed by Tukey–Kramer posttest. The P< 0.05 was considered as significant.

Results:

Based on the result, simvastatin shows dose-dependent cytotoxic effects on both CSCs and parent MCF-7 cells, whereas the apoptosis induction and the elimination of nonapoptotic programmed death were increased in CSC compared with parent cells. In addition, simvastatin showed the …