作者
Jaymin C Patel, Naomi W Lucchi, Priyanka Srivastava, Jessica T Lin, Rungniran Sug-Aram, Supannee Aruncharus, Praveen K Bharti, Man M Shukla, Kanungnit Congpuong, Wichai Satimai, Neeru Singh, Venkatachalam Udhayakumar, Steven R Meshnick
发表日期
2014/10/15
期刊
The Journal of infectious diseases
卷号
210
期号
8
页码范围
1180-1187
出版商
Oxford University Press
简介
Background. To eliminate malaria, surveillance for submicroscopic infections is needed. Molecular methods can detect submicroscopic infections but have not hitherto been amenable to implementation in surveillance programs. A portable loop-mediated isothermal amplification assay called RealAmp was assessed in 2 areas of low malaria transmission.
Methods. RealAmp was evaluated in 141 patients from health clinics in India (passive surveillance) and in 127 asymptomatic persons in Thailand (active surveillance). The diagnostic validity, precision, and predictive value of RealAmp were determined using polymerase chain reaction (PCR) as the reference method. A pilot study of RealAmp was also performed on samples from patients presenting at a Thai health center.
Results. A total of 96 and 7 positive cases were detected in India …
学术搜索中的文章
JC Patel, NW Lucchi, P Srivastava, JT Lin, R Sug-Aram… - The Journal of infectious diseases, 2014