作者
Jeroen JW Liesker, Dirkje S Postma, Rypko J Beukema, Nick HT ten Hacken, Thys Van Der Molen, Roland A Riemersma, Ed H van Zomeren, Huib AM Kerstjens
发表日期
2004/4/1
期刊
Respiratory medicine
卷号
98
期号
4
页码范围
351-356
出版商
WB Saunders
简介
Background
Hypoxemic patients with Chronic Obstructive Pulmonary Disease (COPD) have impaired cognitive performance. These neuropsychological impairments are related to the degree of hypoxemia. So far, cognitive performance has not been tested in non-hypoxemic patients with COPD.
Methods
We recruited patients with stable COPD and PaO2>8.0kPa (60mmHg), as well as healthy subjects, who were matched for age, intelligence quotient (IQ), and level of education. Cognitive performance was studied by Stroop Colour Word Test, Trailmaking, digit-symbol of the Wechsler Adult Intelligence Scale, addition subtest of the Groningen Intelligence Test, and Story Recall.
Results
Thirty patients with COPD (FEV1 49.8% pred, mean age 64.8yr) and 20 healthy volunteers (65.6yr) were enrolled. COPD patients performed significantly worse on trailmaking B, the digit-symbol test, and on the addition subtest. There …
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