作者
Wei-Kai Wu, Chieh-Chang Chen, Po-Yu Liu, Suraphan Panyod, Ben-Yang Liao, Pei-Chen Chen, Hsien-Li Kao, Han-Chun Kuo, Ching-Hua Kuo, Tina HT Chiu, Rou-An Chen, Hsiao-Li Chuang, Yen-Te Huang, Hsin-Bai Zou, Cheng-Chih Hsu, Ting-Yan Chang, Chin-Lon Lin, Chi-Tang Ho, Hon-Tsen Yu, Lee-Yan Sheen, Ming-Shiang Wu
发表日期
2019/8/1
期刊
Gut
卷号
68
期号
8
页码范围
1439-1449
出版商
BMJ Publishing Group
简介
Objective
The gut microbiota-derived metabolite, trimethylamine N-oxide (TMAO) plays an important role in cardiovascular disease (CVD). The fasting plasma TMAO was shown as a prognostic indicator of CVD incident in patients and raised the interest of intervention targeting gut microbiota. Here we develop a clinically applicable method called oral carnitine challenge test (OCCT) for TMAO-related therapeutic drug efforts assessment and personalising dietary guidance.
Design
A pharmacokinetic study was performed to verify the design of OCCT protocol. The OCCT was conducted in 23 vegetarians and 34 omnivores to validate gut microbiota TMAO production capacity. The OCCT survey was integrated with gut microbiome, host genotypes, dietary records and serum biochemistry. A humanised gnotobiotic mice study was performed for translational validation.
Results
The OCCT showed better efficacy than fasting …
学术搜索中的文章
WK Wu, CC Chen, PY Liu, S Panyod, BY Liao… - Gut, 2019