作者
Der-Sheng Han, Wei-Kai Wu, Po-Yu Liu, Yu-Tang Yang, Hsiu-Ching Hsu, Ching-Hua Kuo, Ming-Shiang Wu, Tyng-Guey Wang
发表日期
2022/7/1
期刊
Clinical Nutrition
卷号
41
期号
7
页码范围
1491-1500
出版商
Churchill Livingstone
简介
Background and aims
Despite animal studies revealing a causal link between the gut microbiota and skeletal muscle mass, the role of the gut microbiome and its metabolites in humans having low muscle mass remains unclear.
Methods
Eighty-eight subjects older than 65 years were measured for sarcopenia-related parameters, including body composition, grip strength, gait speed and flexibility. Participants were divided into normal muscle mass group (NM, n = 52) and low muscle mass group (LM, n = 36) and fresh fecal samples were collected for metagenome and short chain fatty acids (SCFAs) analysis.
Results
The richness and evenness of gut microbiota diversity were significantly decreased in the subjects with low muscle mass, including observed ASVs, Shannon and Chao 1 index. A significant difference of gut microbiota profile was noted between NM group and LM group. The Firmicutes/Bacteroidetes ratio …
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