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Objectives:

To study the effect of cell culture extract of Hemidesmus indicus (CCH) on normal and hypercholesterolemic rats for various lipid profile in serum, tissues and fecal matter.

Methods:

Twelve groups of eight animals were subgrouped into three set of experiments. First group received normal and CCH (2, 4 and 16 mg/kg, po) for 30 days, second group received atherogenic diet for 30 (l-30) days and CCH (2, 4 and 16 mg/kg, po) for next 30 (31-60) days, third group received atherogenic diet and CCH (2, 4 and 16 mg/kg, po) for 60 days concurrently. Serum tissue and faecal lipid profile were analysed.

Results:

It was observed that the CCH (2, 4, and 16 mg/kg, po) had prevented hypercholesterolemia in rats. Rats which received atherogenic diet for first 30 (l-30) days when subjected to CCH (2, 4 and 16 mg/kg, po) for next 30 (31-60) days showed significant treatment reduction (p< 0.01) of lipid levels in serum …