作者
Alison J Yarnall, David P Breen, Gordon W Duncan, Tien K Khoo, Shirley Y Coleman, Michael J Firbank, Cristina Nombela, Sophie Winder-Rhodes, Jonathan R Evans, James B Rowe, Brit Mollenhauer, Niels Kruse, Gavin Hudson, Patrick F Chinnery, John T O’Brien, Trevor W Robbins, Keith Wesnes, David J Brooks, Roger A Barker, David J Burn
发表日期
2014/1/28
期刊
Neurology
卷号
82
期号
4
页码范围
308-316
出版商
Lippincott Williams & Wilkins
简介
Objective
To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.
Methods
Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.
Results
The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory impairment was the most common domain affected, with 15.1% impaired at 1.5 SDs. Depression scores were significantly higher in those with PD-MCI than the …
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