作者
Dag Aarsland, K Bronnick, C Williams-Gray, D Weintraub, K Marder, J Kulisevsky, D Burn, Paolo Barone, J Pagonabarraga, L Allcock, Gabriella Santangelo, T Foltynie, C Janvin, JP Larsen, RA Barker, M Emre
发表日期
2010/9/21
期刊
Neurology
卷号
75
期号
12
页码范围
1062-1069
出版商
Lippincott Williams & Wilkins
简介
Background: In studies of mild cognitive impairment (MCI) in Parkinson disease (PD), patients without dementia have reported variable prevalences and profiles of MCI, likely to be due to methodologic differences between the studies.
Objective: The objective of this study was to determine frequency and the profile of MCI in a large, multicenter cohort of well-defined patients with PD using a standardized analytic method and a common definition of MCI.
Methods: A total of 1,346 patients with PD from 8 different cohorts were included. Standardized analysis of verbal memory, visuospatial, and attentional/executive abilities was performed. Subjects were classified as having MCI if their age- and education-corrected z score on one or more cognitive domains was at least 1.5 standard deviations below the mean of either control subjects or normative data.
Results: A total of 25.8% of subjects (95% confidence …
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D Aarsland, K Bronnick, C Williams-Gray, D Weintraub… - Neurology, 2010