作者
Elizabeth L Whitlock, Alexander J Villafranca, Nan Lin, Ben J Palanca, Eric Jacobsohn, Kevin J Finkel, Lini Zhang, Beth A Burnside, Heiko A Kaiser, Alex S Evers, Michael S Avidan
发表日期
2011/12/1
期刊
The Journal of the American Society of Anesthesiologists
卷号
115
期号
6
页码范围
1209-1218
出版商
The American Society of Anesthesiologists
简介
Background
Hypnotic depth during anesthesia affects electroencephalography waveforms and electroencephalogram-derived indices, such as the bispectral index (BIS). Titrating anesthetic administration against the BIS assumes reliable relationships between BIS values, electroencephalogram waveforms, and effect site concentration, beyond loss of responsiveness. Associations among BIS, end-tidal anesthetic concentrations (ETAC), and patient characteristics were examined during anesthetic maintenance, using B-Unaware trial data.
Methods
Pharmacokinetically stable ETAC epochs during intraoperative anesthetic maintenance were analyzed. A generalized estimating equation determined independent relationships among BIS, ETAC (in age-adjusted minimum alveolar concentration equivalents), patient characteristics, and 1-yr mortality. Further individual and population …
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