作者
Lorenzo Ball, Chiara Robba, Lorenzo Maiello, Jacob Herrmann, Sarah E Gerard, Yi Xin, Denise Battaglini, Iole Brunetti, Giuseppe Minetti, Sara Seitun, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti, Patricia RM Rocco, Maurizio Cereda, Lucio Castellan, Nicolò Patroniti, Paolo Pelosi
发表日期
2021/12
期刊
Critical Care
卷号
25
页码范围
1-10
出版商
BioMed Central
简介
Background
There is a paucity of data concerning the optimal ventilator management in patients with COVID-19 pneumonia; particularly, the optimal levels of positive-end expiratory pressure (PEEP) are unknown. We aimed to investigate the effects of two levels of PEEP on alveolar recruitment in critically ill patients with severe COVID-19 pneumonia.
Methods
A single-center cohort study was conducted in a 39-bed intensive care unit at a university-affiliated hospital in Genoa, Italy. Chest computed tomography (CT) was performed to quantify aeration at 8 and 16 cmH2O PEEP. The primary endpoint was the amount of alveolar recruitment, defined as the change in the non-aerated compartment at the two PEEP levels on CT scan.
Results
Forty-two patients were included in this analysis. Alveolar recruitment was median …
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L Ball, C Robba, L Maiello, J Herrmann, SE Gerard… - Critical Care, 2021