作者
Filip Cools, Lisa M Askie, Martin Offringa, Jeanette M Asselin, Sandra A Calvert, Sherry E Courtney, Carlo Dani, David J Durand, Dale R Gerstmann, David J Henderson-Smart, Neil Marlow, Janet L Peacock, J Jane Pillow, Roger F Soll, Ulrich H Thome, Patrick Truffert, Michael D Schreiber, Patrick Van Reempts, Valentina Vendettuoli, Giovanni Vento
发表日期
2010/6/12
来源
The Lancet
卷号
375
期号
9731
页码范围
2082-2091
出版商
Elsevier
简介
Background
Population and study design heterogeneity has confounded previous meta-analyses, leading to uncertainty about effectiveness and safety of elective high-frequency oscillatory ventilation (HFOV) in preterm infants. We assessed effectiveness of elective HFOV versus conventional ventilation in this group.
Methods
We did a systematic review and meta-analysis of individual patients' data from 3229 participants in ten randomised controlled trials, with the primary outcomes of death or bronchopulmonary dysplasia at 36 weeks' postmenstrual age, death or severe adverse neurological event, or any of these outcomes.
Findings
For infants ventilated with HFOV, the relative risk of death or bronchopulmonary dysplasia at 36 weeks' postmenstrual age was 0·95 (95% CI 0·88–1·03), of death or severe adverse neurological event 1·00 (0·88–1·13), or any of these outcomes 0·98 (0·91–1·05). No subgroup of infants …
学术搜索中的文章
F Cools, LM Askie, M Offringa, JM Asselin, SA Calvert… - The Lancet, 2010