作者
Axel R Franz, Corinna Engel, Dirk Bassler, Mario Ruediger, Ulrich H Thome, Rolf F Maier, Ingeborg Krägeloh-Mann, Martina Kron, Jochen Essers, Christoph Bührer, Georg Rellensmann, Rainer Rossi, Hans-Jörg Bittrich, Claudia Roll, Thomas Hoehn, Harald Ehrhardt, Stefan Avenarius, Hans Thorsten Körner, Anja Stein, Horst Buxmann, Matthias Vochem, Christian F Poets, Christian A Maiwald, Gabriele von Oldershausen, Iris Bergmann, Michael Raubuch, Wolfgang Buchenau, Birgit Schuler, Silvia Sander, Hans-Ulrich Bucher, Heike Rabe, Josef Högel, Tamam Bakchoul, Sigrid Enkel, Reinhard Hopfner, Manuel B Schmid, Steffen Ruess, Helmut D Hummler, Maria Zernickel, Christof Dame, Christoph Czernik, Lars Garten, Florian Guthmann, Dieter Hüseman, Elisabeth Walch, Jessica Blank, Esther Rieger-Fackeldey, Claudius Werner, Katja Masjosthusmann, Julia Sandkötter, Isabell Hörnig-Franz, Thomas Kühn, Michael Emeis, Mikosch Wilke, Henriette Schönemann, Kathrin Roefke, Wolfgang Pielemeier, Patrizia Kutz, Laura Stüwe-Kunz, Klaus Lohmeier, Renate Richter-Werkle, Lars Klein, Dirk Faas, Rangmar Goelz, Jörg Arand, Ingo Müller-Hansen, Karen Kreutzer, Cornelia Wiechers, Christoph E Schwarz, Irene Steiner-Wilke, Ralf Böttger, Claudia Jungbluth-Strauch, Janine Heindorf, Christoph Härtel, Levente Bejo, Britta M Hüning, Rolf Schlößer, Doris Fischer, Antje Allendorf, Michael Zemlin, Pia Göbert, Susanne Kampmann, Silke Thomsen, Mirjam Wege, Franziska Heinz, Evelyn Grandmontagne, Martin Wagner, Ulrich Pohlmann, Patrick Neuberger, Thomas Strahleck, Marlene Westmeier, Zoubida El Hafid, Iris Kallenberg, Aurelia Giordano, Annett Bläser, Corinna Gebauer, Jürgen Seidenberg, Jeannette Dege, Birgitt Moed, Orsolya Genzel-Boroviczény, Stefanie Artmann, Rainer Burghard, Mechthild Hubert, Susanne Lüttchens, Bettina Bohnhorst, Corinna Peter, Christoph Jacobi, Barbara Seipolt, Violeta Cerda Ojinaga, Arite Koch, Beate Walter, Hugo Segerer, Annette Keller-Wackerbauer, Jochen Kittel, Norbert Teig, Susanne Wiegand, Almut Weitkämper, Dominique Singer, Sarah Kabisch, Monika Wolf, Mark Schoberer, Thorsten Orlikowsky, Sonja Trepels-Kottek, Victoria Rotering, Catherine Ley, Gernot Buheitel, Wilfried Schenk, Anne C Garbe, Matthias Heckmann, Hagen Bahlmann, Stefan Schäfer, Holger Schiffmann, Bettina Behring, Tanja Bauer, Hans-Georg Topf, Patrick Morhart, Regina Trollmann, Michael Schroth, Angela Kribs, Sandra Zawatzki, Axel von der Wense, Peter Gudowius, Jes Reinholdt Petersen, Gitte Veiergang, Gorm Greisen, Ulla Christensen, Tine Brink Henriksen, Tuuli Metsvaht, Renáta Polácková, ETTNO Investigators
发表日期
2020/8/11
期刊
Jama
卷号
324
期号
6
页码范围
560-570
出版商
American Medical Association
简介
Importance
Red blood cell transfusions are commonly administered to infants weighing less than 1000 g at birth. Evidence-based transfusion thresholds have not been established. Previous studies have suggested higher rates of cognitive impairment with restrictive transfusion thresholds.
Objective
To compare the effect of liberal vs restrictive red blood cell transfusion strategies on death or disability.
Design, Setting, and Participants
Randomized clinical trial conducted in 36 level III/IV neonatal intensive care units in Europe among 1013 infants with birth weights of 400 g to 999 g at less than 72 hours after birth; enrollment took place between July 14, 2011, and November 14, 2014, and follow-up was completed by January 15, 2018.
Interventions
Infants were randomly assigned to liberal (n = 492) or restrictive (n = 521) red blood cell transfusion thresholds based on infants’ postnatal age and current health state …
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AR Franz, C Engel, D Bassler, M Ruediger, UH Thome… - Jama, 2020