作者
Erik S Stroes, Paul D Thompson, Alberto Corsini, Georgirene D Vladutiu, Frederick J Raal, Kausik K Ray, Michael Roden, Evan Stein, Lale Tokgözoğlu, Børge G Nordestgaard, Eric Bruckert, Guy De Backer, Ronald M Krauss, Ulrich Laufs, Raul D Santos, Robert A Hegele, G Kees Hovingh, Lawrence A Leiter, Francois Mach, Winfried März, Connie B Newman, Olov Wiklund, Terry A Jacobson, Alberico L Catapano, M John Chapman, Henry N Ginsberg, European Atherosclerosis Society Consensus Panel, Erik Stroes, Paul D Thompson, Alberto Corsini, Georgirene D Vladutiu, Frederick J Raal, Kausik K Ray, Michael Roden, Evan Stein, Lale Tokgözoğlu, Børge G Nordestgaard, Eric Bruckert, Ronald M Krauss, Ulrich Laufs, Raul D Santos, Winfried März, Connie B Newman, M John Chapman, Henry N Ginsberg, M John Chapman, Henry N Ginsberg, Guy de Backer, Alberico L Catapano, Robert A Hegele, G Kees Hovingh, Terry A Jacobson, Lawrence Leiter, Francois Mach, Olov Wiklund
发表日期
2015/5/1
来源
European heart journal
卷号
36
期号
17
页码范围
1012-1022
出版商
Oxford University Press
简介
Statin-associated muscle symptoms (SAMS) are one of the principal reasons for statin non-adherence and/or discontinuation, contributing to adverse cardiovascular outcomes. This European Atherosclerosis Society (EAS) Consensus Panel overviews current understanding of the pathophysiology of statin-associated myopathy, and provides guidance for diagnosis and management of SAMS. Statin-associated myopathy, with significant elevation of serum creatine kinase (CK), is a rare but serious side effect of statins, affecting 1 per 1000 to 1 per 10 000 people on standard statin doses. Statin-associated muscle symptoms cover a broader range of clinical presentations, usually with normal or minimally elevated CK levels, with a prevalence of 7–29% in registries and observational studies. Preclinical studies show that statins decrease mitochondrial function, attenuate energy production, and alter muscle protein …
学术搜索中的文章
ES Stroes, PD Thompson, A Corsini, GD Vladutiu… - European heart journal, 2015