作者
David Preiss, Sreenivasa Rao Kondapally Seshasai, Paul Welsh, Sabina A Murphy, Jennifer E Ho, David D Waters, David A DeMicco, Philip Barter, Christopher P Cannon, Marc S Sabatine, Eugene Braunwald, John JP Kastelein, James A de Lemos, Michael A Blazing, Terje R Pedersen, Matti J Tikkanen, Naveed Sattar, Kausik K Ray
发表日期
2011/6/22
期刊
Jama
卷号
305
期号
24
页码范围
2556-2564
出版商
American Medical Association
简介
Context
A recent meta-analysis demonstrated that statin therapy is associated with excess risk of developing diabetes mellitus.
Objective
To investigate whether intensive-dose statin therapy is associated with increased risk of new-onset diabetes compared with moderate-dose statin therapy.
Data Sources
We identified relevant trials in a literature search of MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials (January 1, 1996, through March 31, 2011). Unpublished data were obtained from investigators.
Study Selection
We included randomized controlled end-point trials that compared intensive-dose statin therapy with moderate-dose statin therapy and included more than 1000 participants who were followed up for more than 1 year.
Data Extraction
Tabular data provided for each trial described baseline characteristics and numbers of participants developing diabetes and experiencing major …
引用总数
学术搜索中的文章
D Preiss, SRK Seshasai, P Welsh, SA Murphy, JE Ho… - Jama, 2011