作者
Travis Dunckley, Matthew J Huentelman, David W Craig, John V Pearson, Szabolcs Szelinger, Keta Joshipura, Rebecca F Halperin, Chelsea Stamper, Kendall R Jensen, David Letizia, Sharon E Hesterlee, Alan Pestronk, Todd Levine, Tulio Bertorini, Michael C Graves, Tahseen Mozaffar, Carlayne E Jackson, Peter Bosch, April McVey, Arthur Dick, Richard Barohn, Catherine Lomen-Hoerth, Jeffrey Rosenfeld, Daniel T O'Connor, Kuixing Zhang, Richard Crook, Henrik Ryberg, Michael Hutton, Jonathan Katz, Ericka P Simpson, Hiroshi Mitsumoto, Robert Bowser, Robert G Miller, Stanley H Appel, Dietrich A Stephan
发表日期
2007/8/23
期刊
New England journal of medicine
卷号
357
期号
8
页码范围
775-788
出版商
Massachusetts Medical Society
简介
Background
Approximately 90% of persons with amyotrophic lateral sclerosis (ALS) have the sporadic form, which may be caused by the interaction of multiple environmental factors and previously unknown genes.
Methods
We performed a genomewide association analysis using 766,955 single-nucleotide polymorphisms (SNPs) found in 386 white patients with sporadic ALS and 542 neurologically normal white controls (the discovery series). Associations of SNPs with sporadic ALS were confirmed in two independent replication populations: replication series 1, with 766 case patients with the disease and 750 neurologically normal controls, and replication series 2, with 135 case patients and 275 controls.
Results
We identified 10 genetic loci that are significantly associated (P<0.05) with sporadic ALS in three independent series of case patients and controls and an additional 41 loci that had significant …
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T Dunckley, MJ Huentelman, DW Craig, JV Pearson… - New England journal of medicine, 2007