作者
Zulfiqar A Bhutta, Sheila M Bird, Robert E Black, Kenneth H Brown, Julie Meeks Gardner, Adi Hidayat, Farida Khatun, Reynaldo Martorell, Nguyen X Ninh, Mary E Penny, Jorge L Rosado, Swapan K Roy, Marie Ruel, Sunil Sazawal, Anuraj Shankar, The Zinc Investigators’Collaborative Group
发表日期
2000/12/1
期刊
The American journal of clinical nutrition
卷号
72
期号
6
页码范围
1516-1522
出版商
Elsevier
简介
Background
Zinc deficiency is prevalent in children in developing countries. Supplemental zinc provides therapeutic benefits in diarrhea.
Objective
We sought to measure the effect of supplemental zinc given with oral rehydration therapy during recovery from acute or persistent diarrhea.
Design
We conducted pooled analyses including all available published and unpublished randomized controlled trials of the effects of supplementary oral zinc in children aged <5 y with acute or persistent diarrhea. We used Cox survival regression analysis to evaluate the overall effect of zinc on continuation of diarrhea and possible differential effects in subgroups divided by sex, age, weight-for-height, and initial plasma zinc concentration. Dichotomous outcomes were analyzed by logistic regression. To assess the effects of excluding studies without original data from the pooled analyses, effect-size was estimated for all studies by …
引用总数
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ZA Bhutta, SM Bird, RE Black, KH Brown, JM Gardner… - The American journal of clinical nutrition, 2000
MB Sheila, EB Robert, HB Kenneth, MG Julie, H Adi - Am J Clin Nutr, 2000