作者
Sara E Jager, Lone T Pallesen, Mette Richner, Peter Harley, Zoe Hore, Stephen McMahon, Franziska Denk, Christian B Vægter
发表日期
2020/7
期刊
Glia
卷号
68
期号
7
页码范围
1375-1395
出版商
John Wiley & Sons, Inc.
简介
Satellite glial cells (SGCs) are homeostatic cells enveloping the somata of peripheral sensory and autonomic neurons. A wide variety of neuronal stressors trigger activation of SGCs, contributing to, for example, neuropathic pain through modulation of neuronal activity. However, compared to neurons and other glial cells of the nervous system, SGCs have received modest scientific attention and very little is known about SGC biology, possibly due to the experimental challenges associated with studying them in vivo and in vitro. Utilizing a recently developed method to obtain SGC RNA from dorsal root ganglia (DRG), we took a systematic approach to characterize the SGC transcriptional fingerprint by using next‐generation sequencing and, for the first time, obtain an overview of the SGC injury response. Our RNA sequencing data are easily accessible in supporting information in Excel format. They reveal that SGCs …
引用总数
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