作者
Rafael de la Torre, Susana de Sola, Gimena Hernandez, Magí Farré, Jesus Pujol, Joan Rodriguez, Josep María Espadaler, Klaus Langohr, Aida Cuenca-Royo, Alessandro Principe, Laura Xicota, Nathalie Janel, Silvina Catuara-Solarz, Gonzalo Sanchez-Benavides, Henri Bléhaut, Iván Dueñas-Espín, Laura Del Hoyo, Bessy Benejam, Laura Blanco-Hinojo, Sebastiá Videla, Montserrat Fitó, Jean Maurice Delabar, Mara Dierssen
发表日期
2016/7/1
期刊
The Lancet Neurology
卷号
15
期号
8
页码范围
801-810
出版商
Elsevier
简介
Background
Early cognitive intervention is the only routine therapeutic approach used for amelioration of intellectual deficits in individuals with Down's syndrome, but its effects are limited. We hypothesised that administration of a green tea extract containing epigallocatechin-3-gallate (EGCG) would improve the effects of non-pharmacological cognitive rehabilitation in young adults with Down's syndrome.
Methods
We enrolled adults (aged 16–34 years) with Down's syndrome from outpatient settings in Catalonia, Spain, with any of the Down's syndrome genetic variations (trisomy 21, partial trisomy, mosaic, or translocation) in a double-blind, placebo-controlled, phase 2, single centre trial (TESDAD). Participants were randomly assigned at the IMIM-Hospital del Mar Medical Research Institute to receive EGCG (9 mg/kg per day) or placebo and cognitive training for 12 months. We followed up participants for 6 months …
学术搜索中的文章
R de la Torre, S de Sola, G Hernandez, M Farré, J Pujol… - The Lancet Neurology, 2016