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Objective: The objective of the study was to reevaluate the diagnostic accuracy of GH peak after GHRH plus arginine test (GHRH+ARG) according to patients’ age, body mass index (BMI), and waist circumference to diagnose GH deficiency (GHD).

Outcome Measures: GH peak after GHRH+ARG and IGF-I levels reported as sd score.

Subjects: Subjects included 408 controls (218 women, 190 men, aged 15–80 yr) and 374 patients with hypopituitarism (167 women, 207 men, aged 16–83 yr).

Results: In the (elderly) healthy subjects 15–25 yr old (young), 26–65 yr old (adults) and older than 65 yr, GH cutoffs were 15.6, 11.7, and 8.5 μg/liter, 11.8, 8.1, and 5.5 μg/liter, and 9.2, 6.1, and 4.0 μg/liter, respectively, in the lean, overweight, and obese subjects. Waist circumference was the best predictor of GH peak (t = −7.6, P < 0.0001) followed by BMI (t = −6.7, P < 0.0001) and age (t = −5 …